Panama is known for many things. The canal, wonderful climate, and beautiful beaches are just a few great aspects of this beautiful country. Panama City, however, is typically known for its own different sect of attributes. Casinos, beautiful girls, and the club scene are, in my opinion, the top three. When considering places to party in Panama you will never run out of clubs and bars to visit as it seems new ones are 
popping up every week.
A new hot spot among places to party in the city is Zona Viva. Zona Viva is not a single club, but a flood of bars, restaurants and dance clubs which always seem to be packed after 12 a.m. on any Thursday, Friday or Saturday night. The clubs range from upscale to outdoor bar/lounge type locals which make for great variety of people and atmosphere to suit your mood. Beers can range from $2 to $4 and bottles at most places in Zona Viva will usually range from $35 to $75 depending on your pick of poison. When you visit be sure to hit up club Heaven (if the name hasn’t changed yet) and you will be probably be greeted by some gorgeous ladies in white dresses, halos and wings as well as receive first class service and drinks (especially if they think you are a tourist). Panama has plenty of places to party. However, hopping cabs from club to club in the city can become expensive and possibly dangerous if done alone or too late at night. Zona Viva has the variety to keep even the most attention deficit partier content for an evening and a ride to and from is easily arranged beforehand.
Zona Viva is located near the entrance of the Amador Causeway and next to the Figali Convention Center.
The Big Gringo travels around Central and South America checking out the hot spots on your behalf and then reporting back. Find out more about Guatemala at this website about ==> The Guatemala Gringo.
recommend in addition to those places, HAVANA, SCENA PLATEA both have live music, salsa music on Fridays and many foreigners Aided
There is one on 50th Street, but the most Panamanians will not believe you feel comfortable
Zona Viva should be increasing its security soon, making it even more attractive.
http://www.thepanamadigest.com/2010/09/shootout-on-the-zona-viva-nightclub-strip/
[...] atmosphere, offering a multitude of trendy Miami-style bars, casinos and clubs such as Pure Lounge, Zona Viva and Relic. Tagged Private islands Private island properties Properties in Panama luxury [...]